A 24-month postdoctoral_position is available at the Centre de Résonance Magnétique Biologique et Médicale (CRMBM, UMR7339, CNRS/Aix-Marseille Université/APHM), located in Marseille, France. The position will focus on identifying early biomarkers of neurodegeneration related to isolated REM-sleep Behavior Disorders (iRBD), Parkinson’s disease (PD), and atypical parkinsonism using a 7T brain MRI. The aim is to better understand the underlying pathophysiology and facilitate an early differential diagnosis between PD and other clinically related disorders. These biomarkers consist of an evaluation of brain tissue microstructure (cortical thickness, basal ganglia and brainstem volume and deformation), ion homeostasis (sodium), neuromelanin, iron load, and connectivity. Also, correlations with clinical symptoms (motor, dysautonomic, and cognitive) are looked for.

Date de début: Janvier 2025 pour 24 mois

Lieu : CEMEREM/CRMBM, Marseille, France

Le projet vise à identifier des biomarqueurs précoces de neurodégénérescence dans les syndromes parkinsoniens , y compris au stade du trouble du comportement en sommeil paradoxal isolé, à l’aide d‘une IRM à très haut champ (7 Tesla).

Le profil recherché est un.e titulaire d’un doctorat en imagerie médicale, biomédecine, physique, ingénierie ou dans un domaine proche avec des compétences techniques avancées en traitement du signal ou en reconstruction d’images et en programmation dans au moins l’un des langages suivants : Python, Matlab ou C++. La maîtrise du français n’est pas indispensable (doit alors maitriser l’anglais).

CV, liste de publications et lettre de motivation à envoyer à Stephan Grimaldi: stephan.grimaldi@ap-hm.fr (PI supervisor) au mieux avant le 1er novembre 2024.

Starting date: January 2025 for 24 months

Location : CEMEREM/CRMBM, Marseille, France

The position will focus on identifying early biomarkers of neurodegeneration related to isolated REM-sleep Behavior Disorders (iRBD), Parkinson’s disease (PD), and atypical parkinsonism using a 7T brain MRI.

The candidate should have a PhD in medical imaging, biomedicine, physics, engineering, or related field  and should also show advanced technical skills in either signal processing, image reconstruction and in programming in at least one of these languages: Python, Matlab or C++. Speaking French is not a requirement (in this case, English speaking is required).

Please send your CV, cover letter, list of publications before (if possible) November 1st 2024 to Stephan Grimaldi: stephan.grimaldi@ap-hm.fr (PI supervisor)